Autoimmune Calcium Channelopathies and Cardiac Electrical Abnormalities
نویسندگان
چکیده
منابع مشابه
Understanding cardiac calcium channelopathies.
Timothy syndrome is a rare genetic disorder characterized by QT prolongation (designated LQT8), arrhythmias and sudden death, structural heart disease, cognitive defects with autism, syndactyly (webbed fingers and toes), hypoglycemia, and immune deficiencies.1,2 A single mutation (G406R) in exon 8a of the cardiac L-type calcium channel (CACNA1C, Cav1.2, 1c) was shown to cause Timothy syndrome i...
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Introduction Calcium (Ca2+) is an essential signalling molecule is known about the VGCC with reference to these diseases and to speculate on the implications for in many biological systems, and normal intracellular other human diseases. calcium levels at ~100 nM are 20 000-fold lower than the 2 mM concentration found extracellularly. Homoeostatic mechanisms are tightly controlled to enable Ca2+...
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Ion channels are crucial elements in neuronal signaling and synaptic transmission, and defects in their function are known to underlie rare genetic disorders, including some forms of epilepsy. A second class of channelopathies, characterized by autoantibodies against ligand- and voltage-gated ion channels, cause a variety of defects in peripheral neuromuscular and ganglionic transmission. There...
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Atrial fibrillation is the commonest arrhythmia encountered in day-to-day clinical practice. Its prevalence is increasing due to increasing age of the population, increasing prevalence of chronic heart disease and better diagnostic techniques. It is an extremely costly public health problem. It increases stroke, heart failure and mortality. Mortality is doubled by the presence of atrial fibrill...
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2019
ISSN: 2297-055X
DOI: 10.3389/fcvm.2019.00054